Creutzfeldt-Jakob Disease

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Risk Factors and Causes

Sporadic CJD develops when normal prions spontaneously change into infectious prions and then alter other cells. Infectious prions stick together, forming fibers and plaques that accumulate in brain tissue. These fibers and plaques can be detected years before CJD symptoms develop.


Familial CJD is caused by a genetic abnormality (mutation) that results in infectious prion formation. Several types of prion gene mutations have been identified, and the specifi...Read the full article